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To develop potent antitumor polysaccharides from higher fungi of Korea the alcohol precipitated polysaccharides, which were obtained from hot water extracts of shake-cultured mycelia of eight species of basidiomycetes, were subjected to antitumor screening tests, using sarcoma 180 as a tumor cell. When administered i.p., at the dose level of 20mg/kg/day for ten days into the mice which were implanted with 1 X 106 cells of sarcoma 180 twenty-four hour before the start of polysaccharide injection, the polysaccharides of Pluteus cervinus ISA-Pc-1004, Pleurotus pulmonarius, Hydnum repandum ISA-Hr-1006, and Laccaria laccata ISA-Ll-1008 respectively showed inhibition ratios of 62.0%, 51.7%, 64.8% and 57.8%. They were selected for further study, while those of Panellus serotina ISA-Ps-1012, Laccaria amethystina ISA-La-1001, Pholiota adiposa ISA-Pa-1010, and Lepista sp.ISA-Ls-1007 respectively showed inhibition ratios of -9.3%, 25.3%, 27.3% and 33.0%.
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